B-cell epitopes: Discontinuity and conformational analysis
نویسندگان
چکیده
منابع مشابه
An analysis of B-cell epitope discontinuity
Although it is widely acknowledged that most B-cell epitopes are discontinuous, the degree of discontinuity is poorly understood. For example, given that an antigen having a single epitope that has been chopped into peptides of a specific length, what is the likelihood that one of the peptides will span all the residues belonging to that epitope? Or, alternatively, what is the largest proportio...
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MOTIVATION B-cell epitope is a small area on the surface of an antigen that binds to an antibody. Accurately locating epitopes is of critical importance for vaccine development. Compared with wet-lab methods, computational methods have strong potential for efficient and large-scale epitope prediction for antigen candidates at much lower cost. However, it is still not clear which features are go...
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B-cell epitopes are regions of the antigen surface which can be recognized by certain antibodies and elicit the immune response. Identification of epitopes for a given antigen chain finds vital applications in vaccine and drug research. Experimental prediction of B-cell epitopes is time-consuming and resource intensive, which may benefit from the computational approaches to identify B-cell epit...
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The prediction of conformational b-cell epitopes plays an important role in immunoinformatics. Several computational methods are proposed on the basis of discrimination determined by the solvent-accessible surface between epitopes and non-epitopes, but the performance of existing methods is far from satisfying. In this paper, depth functions and the k-th surface convex hull are used to analyze ...
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Immunoglobulin molecules are folded in a way that assembles sequences from the variable regions of both the heavy and light chains into a surface feature (comprised of up to six complementarity-determining regions (CDRs)) that is complementary in shape to a surface structure on the antigen. These two surface features, the ‘paratope’ on the antibody and the ‘epitope’ on the antigen, may have a c...
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ژورنال
عنوان ژورنال: Molecular Immunology
سال: 2019
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2019.09.014